In spite of their many make ups and break ups, however, Arquette and the Hung star aren't ending their marriage on a bad note.
When asked last year how they were doing in the wake of the breakup, Arquette told E! News, "We're both really good. I don't think people would even imagine that it could be so friendly and not weird."
The ex-couple, who tied the knot in May 2006, has an eight-year-old daughter together, Harlow Olivia Calliope.
This was the second marriage for Jane, as well as Arquette, who was previously married to Nicolas Cage.