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Chelsea Handler, Angelina Jolie

Frederick M. Brown/Getty Images; Mike Marsland/WireImage.com

Jennifer Aniston's new BFF isn't the biggest fan of Angelina Jolie. Shocker, right?

Which is why E!'s resident funnylady Chelsea Handler went on something of a verbal rampage against Brad Pitt's current better half while performing in Newark Friday night.

And yes, she went all the way there.

In addition to labeling the actress a See You Next Tuesday, Handler also pulled Jolie's adopted son Maddox into the fray, theorizing that he would most likely prefer to be chillaxing in Malibu than on one of his parents' perpetual goodwill tours.

And then there was the matter of Angelina's all too frequent profession of not having any female friends.

"She's a homewrecker, she is," Handler said. "She can rescue as many babies from as many countries as she wants to, I don't f--king believe you.

"Because when I look into a woman's eyes and she gives interviews, and she goes, 'Oh, I don't have a lot of female friends'…'cause you're a f--king c--t, that's why. That's why. You're a female and you don't have female friends, you're a f--king bitch."

So while we're not totally sure Jen would be on board with Chelsea's outburst (if there's one storyline that doesn't need any help resurfacing, it's that of her as a pitiable, wronged woman), we think Handler's heart was in the right place.

Even if her potty mouth wasn't.