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Chelsea Handler, Twitpic, Twitter

Twitter

Cougar catfight!

Chelsea Handler is honing in on the May-December pseudo-romance between Justin Bieber and fellow E! star Kim Kardashian.

Last night, the VMAs host tweeted a picture of herself embracing the VMA Best New Artist winner with this warning: "@kimkardashian watch your armenian back, girl."

It's a bold move for the Chelsea Lately host: Bieber's original tweetheart received death threats from his fans after he tweeted a similar picture with Kardashian, calling the reality star his "girlfriend."

We have to ask: Will any other of our E! pals brave the wrath of Bieber Nation by making a move on the tween sensation?

Your move, Seacrest.

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See what other stars are up to in our Tweet Peeks gallery!