It's a bold move for the Chelsea Lately host: Bieber's original tweetheart received death threats from his fans after he tweeted a similar picture with Kardashian, calling the reality star his "girlfriend."
We have to ask: Will any other of our E! pals brave the wrath of Bieber Nation by making a move on the tween sensation?
Your move, Seacrest.
See what other stars are up to in our Tweet Peeks gallery!