We'll find out next Sunday at the 62nd Primetime Emmy Awards, when the crashed crew competes with a chemistry criminal, a family-man murderer, a not-so-good Wife, a few Mad Men and some blood-thirsty vampires.
But first, it's your turn! Which series will take home the Emmy for Outstanding Drama Series? Take the poll and let us know:
PHOTOS: 2010 Emmys: Notable Nominees