After watching the sneak peek video above for next week's 100th episode of Grey's Anatomy, we finally get what Grey's show runner Shonda Rhimes meant when she said, "We should all remember what [Denny's] appearance means." Clearly, it means death. Denny (Jeffrey Dean Morgan) is the Grim Reaper, come for Izzie's (Katherine Heigl) soul and for her irradiated, falling-out hair. Sob.

In other, happier Grey's news, Meredith (Ellen Pompeo) and Derek (Patrick Dempsey) are gettin' married! See the bride and groom below and five more sneak peeks clips below...

Grey's Anatomy's 100th episode, "What a Difference a Day Makes," airs May 7 at 9 p.m. on ABC. Will you be watching?

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