From cutthroat journalist to blood-sucking vampire.
In the new film due out this fall, Sheen, 40, will play Aro, the leader of the deadly Volturi vampire coven that wants to ensure humans never find out bloodsuckers exist.
Sheen is best known for playing David Frost in last year's Oscar-nominated Frost/Nixon and as former British Prime Minister Tony Blair in 2006's Oscar-winning film The Queen with Helen Mirren.
New Moon isn't the first movie in which Sheen portrays a monster: He also appeared in 2003's Underworld starring Kate Beckinsale, with whom he has a daughter.
(Originally published April 12, 2009, at 7:45 a.m. PT)