Laughter may not be the best medicine when it comes to repairing a relationship.
The 41-year-old talk-show host and the 38-year-old funnywoman first announced their breakup in July 2008 but had rekindled their romance by fall.
The former couple, who began dating six years ago, were seen together at Howard Sterns NYC nuptials in October, and later that month Silverman poked fun at their breakup when she appeared as a guest on Jimmy Kimmel Live.
Their reunion was cemented when they showed up arm in arm at GQ's Man of the Year party in November.
When contacted by E! about news of the recent split, both reps declined to comment.