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"Who better to spend Hump Day with than Anderson Cooper?" Kelly Ripa asked Wednesday on LIVE With Kelly.

Who indeed. Or any day, many would argue.

The 48-year-old CNN personality guest co-hosted the daytime talk show, marking his 40th such stint and the first time he has joined Ripa, 45, as her co-host since Michael Strahan left the position last month after more than three years.

Cooper joins several other popular TV personalities who have in recent weeks guest co-hosted LIVE, whose title has been changed over the years amid casting shakeups, and he is widely seen as a possible contender to replace Strahan.

Fans have often noted the chemistry Ripa and Cooper share and Wednesday was no exception. They even got frisky on and off-screen.

"What happened backstage that you guys don't know is that Anderson pulled me into a dance move and I don't know if it was seeing Gloria Estefan backstage or what happened to you...and then his feet went, this cockamamie thing happened," Ripa said.

"I was joking around, because I go down to Brazil a lot and Samba is very popular in Brazil," Cooper said. "And I don't know how the dance. I'm a terrible dancer, I don't even attempt to dance, I don't like dancing in public, I get embarrassed about it but I enjoy trying to dance."

"He pulls me in and then he starts doing the Charleston! Ripa said.

The two then reenacted their awkward dance moment.

"I was like, 'We just made a baby. We made a baby,'" Ripa said.

Also during the show, Ripa and Cooper got to try out some acrobatic dance moves with a fitness instructor. 

Anderson Cooper, Kelly Ripa, Live! With Kelly

WABC

The two are also friends in real life—they spent Memorial Day weekend together at his home in Connecticut, along with Ripa, her husband Mark Consuelos, 46, and their family.

The other celebs who have guest co-hosted LIVE With Kelly since Strahan left, and could possibly take over for him long-term, are:

Mark Consuelos: Ripa's husband has co-hosted LIVE with her more than 40 times since 2005 and will return to the show to do it again this Friday.

Jussie Smollett: The 32-year-old actor, who plays Jamal Lyon on FOX's Empire, has guest co-hosted the show twice overall, both times after Strahan's departure, and has appeared on the series as a guest twice as well.

Cedric the Entertainer: The 52-year-old actor guest co-hosted LIVE for the first time days after Strahan left and has appeared as a guest five times prior.

David Muir: The 42-year-old host of ABC's World News Tonight guest co-hosted LIVE for the first time in 2014 and returned to do it again the day after Cedric the Entertainer. He has appeared as a guest three times before.

Daniel Dae Kim: The 47-year-old LOST alum and Hawaii Five-0 actor guest co-hosted LIVE for the first time in 2012, after host Regis Philbin, 84, left the show after 28 years and before Strahan was announced as his replacement, and joined Ripa for the second time last month, a week after the latter's departure. Kim has appeared as a guest on the series five times.

Fred Savage: The 39-year-old Wonder Years alum, who this year starred with Rob Lowe on the now-canceled series The Grinder, made his debut as a LIVE guest co-host in April and also joined Ripa by her side for two shows last week. He has appeared as a guest on the series once.

Seal The 53-year-old singer made his LIVE guest co-hosting debut last week and has appeared as a guest four times prior.

Andy Cohen Like Cooper, the 47-year-old host of Bravo's Watch What Happens Live is a fan-favorite frequent LIVE guest co-host. He made his debut in early 2011, after Philbin announced he was leaving the show, and has guest co-hosted with Ripa five times, most recently last week. He has also appeared as a guest on LIVE five times.

In April, Cohen hosted Cooper on his own show and asked him if he would be open to co-hosting LIVE, to which he replied, "Look, I'm very happy at CNN. It would be a dream to work with Kelly, but nobody's offering anything, so..." 

Andy Cohen, Kelly Ripa, Michael Strahan

Jamie McCarthy/Getty Images for SiriusXM, Gary Gershoff/WireImage

Common The 44-year-old rapper guest co-hosted LIVE for the first time last week and has appeared as a guest six times, the first being in 2005.

In addition, Jimmy Kimmel, 48, guest co-hosted the first LIVE taping after Strahan left and has assumed the role 13 times since 2005. However, last month, ABC renewed his contract to host his late-night talk show Jimmy Kimmel Live! for three years, through fall 2019. The show is taped in Los Angeles, while LIVE films in New York.

Of course, guest co-hosting frequency may not be a deciding factor for ABC when picking Ripa's new co-host. Strahan had assumed the role only twice before Philbin left.

Also, there are other popular past LIVE guest co-hosts who have not reunited with Ripa on the show since Strahan's departure. The list includes LoweJerry Seinfeld, Neil Patrick Harris, Nick Lachey, Jim ParsonsJonah Hill and Alec Baldwin.