Deana Newcomb/ Summit Entertainment

Now that's buying power.

A femaie-dominated audience drove Twilight's opening weekend to among the biggest in Hollywood history: a $70.6 million Friday-Sunday gross, per studio estimate. 

"This is a game-changer. This is an industry-changing performance," Exhibitor Relations analyst Jeff Bock said today. "…With the success of Sex and the City, and Mamma Mia!, we've awoken a sleeping giant at the box office."

Exit polling showed 75 percent of Twilight's audience was female. Box-office stats show the movie is the biggest opener for a movie directed by a woman (Catherine Hardwicke).

The vampire romance also played well to the young—overall, 55 percent of ticketbuyers were under age 25.

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