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Giuliana Rancic is Going Off Script in more ways than one.

During Monday's Today, Savannah Guthrie noted that Rancic has "been in the headlines" more often than usual in recent months. Recently, critics became concerned that Rancic looks too "skinny" on TV.

The E! News host first opened up about the scrutiny in People's Apr. 13 issue.

"It was something that I didn't feel I ever needed to talk about, because I think weight is very personal, whether you're underweight, overweight, whatever! It's your business. But it became distracting," she told Guthrie. "I would do a two-hour red carpet show and I would be so proud of these interviews, so many fun moments, and I would go on the Internet afterwards just to see 99 percent of the comments about my weight, and not about the interviews. I basically found it very distracting and I thought, 'You know what? I think it's time to just tell the truth and tell people what's going on.'" Guthrie pressed on, asking Rancic, "What's going on? Because you are, in fact, very thin. Do you have an eating disorder?"

Giuliana Rancic, Instagram

Instagram

"I do not have an eating disorder. I never have had an eating disorder," Rancic replied. "I want to be very clear about that. In fact, I eat a lot. People love to tweet, 'Eat a burger.' I eat burgers! It's not working!"

Rancic, who underwent a double mastectomy after being diagnosed with breast cancer in 2011, said she lost "a considerable amount of weight" in recent years "due to the cancer medication" she had been prescribed. "I was eating more than I've ever eaten but I was losing weight, and I was scared! I didn't think, 'Oh, this is great.' I thought, 'What the heck's happening to my body?' It's very scary to have cancer and be on medication. Then to start losing weight, I thought, 'Oh, my gosh. Is the cancer back?'" she said. "I went to my doctor and he said, 'A side effect from the medication you're on is weight loss.'"

Tune in to E! News weeknights at 7 and 11, only on E!

(E! and NBC are both members of the NBCUniversal family.)