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Giuliana Rancic

Steve Granitz/WireImage

Giuliana Rancic's weight has been the topic of many conversations since her appearance at the 2015 Golden Globes, but after the scrutiny had "gotten out of hand," the E! News anchor is finally speaking out about what is going on with her health...and body.

"Some people were saying, 'The cancer is probably back,'" Rancic, who was diagnosed with breast cancer in 2011 and underwent a double mastectomy that same year, dishes to People magazine, on newsstands Friday. "And they were accusing me of every eating disorder. I thought to myself, 'God, if someone really thought I had an eating disorder, what a horrible way to approach it.'"  

Fortunately the 40-year-old E! star doesn't have an eating disorder and is still cancer-free, but reveals her low weight is a result of a cancer-suppressing medication that she has been taking since 2012. "I started noticing that I was eating a lot, but not gaining weight at all," Rancic says. "I was concerned."

Rancic's oncologist, Dr. Dev Paul, informed her that the medication could alter her metabolism and cause weight loss. Despite facing criticism on a daily basis about her weight, she is just grateful that she continues to be happy and healthy with her family, which includes husband Bill Rancic and, of course, adorable son Duke Rancic!

"It's really hurtful," Rancic says of the negative attention. "I'm sorry that some people think I'm disgustingly skinny, as they put it, but there's nothing I can do. I'm lucky that I even have the type of cancer that reacts to the medicine."

She maintains that her appetite hasn't changed even though she can't gain weight. In fact, the Fashion Police host confesses she eats more than anyone she knows.

"I eat more than any of my friends," she says. "I eat a very robust, healthy, balanced diet and dessert almost every night. I'm not hiding from anything."

Even though she has an overall positive outlook and attitude, the overwhelming criticism has taken its toll on Rancic, especially when it comes to her self-esteem. "I look in the mirror and it's hard for me," she admits. "I am really thin. I want to look fit and beautiful and sexy, and I can't."

She was upset when a high-profile publication wanted to feature her but backed out because she was too thin, something that she described as "really hurtful" because she's "doing the best" she can.

"I never want my weight to distract people from what I do," she says. "But it is becoming a distraction, [whenever] I wear something sleeveless, show my arms, my back."