The blushing bride was seen leaving the final venue of the evening with hives all across her face and neck. Beyoncé was in the backseat of the same chauffeured vehicle with her, and was snapped covering her little sister's face with a white coat jacket.
Jay-Z, meanwhile, was spotted sitting in the front passenger seat of the car and chatting with the Knowles ladies as they made their way to their hotel.
The incident didn't seem to put a damper on the overall weekend, however, and the photos depict a family-filled celebration that everyone enjoyed.
After a weekend of festivities, close to 100 guests attended a New Orleans church Sunday afternoon to see the happy duo wed.
Vogue magazine reports that Solange walked down the aisle to an instrumental version of Donny Hathaway's "I Love the Lord, He Heard Me Cry," which is said to be a favorite of the bride and groom.
And the party was in full effect after the romantic reception, with performances by Kelela, Questlove and Kindness.
There was also an amazing dance performance between Solange and her son Julez, 10, to "No Flex Zone." The two showed off their choreographed dance in front of guests and were the life of the party.
"The couple looked happy, relaxed and beaming," an eyewitness told E! News. "It was a very chill vibe."
Following the dinner and dance party, guests walked along the streets of NoLa with sparklers and danced in celebration of the new Mr. and Mrs. Ferguson.
Bey and Jay kept close and cheered on as Solange and her hubby lead the jubilant procession.
In an email exchange with Vogue, the 28-year-old opened up about her beautiful wedding day.
"Everyone I worked with on the wedding are friends who I love. Everything was a labor of love."