In Due Date, director Todd Phillips' followup to The Hangover, the pair team up for a crosscountry adventure as Downey's character races to the hospital in order to make for the birth of his child. Aww.
Only as the trailer shows, the obstacles to this quest are Galifianakis, his tiny dog and his enormous assortment of issues: he's allergic to waffles, but eats them anyway; he's a menace around firearms and he's prone to saying things like, "Check yourself before you wreck yourself." Good luck, RDJ.
So think you'll be up for a road trip with these two (and Jamie Foxx)?