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We all remember the shock we felt when a mangled George (T.R. Knight) scribbled "007" on Meredith's (Ellen Pompeo) hand, and now we must relive it all over again.

When Grey's Anatomy returns Sept. 24 with a two-hour season premiere, most fans will already know who's kicking the bucket and who's living to see another day. However, ABC isn't giving it up that easily. In the promo above, the only clue you get is Callie's (Sara Ramirez) reaction to something cataclysmic. We all know Callie and Izzie Stevens (Katherine Heigl) never got along, so she must be mourning George's death, right?

Are you going to cry like Callie during the season premiere? Check out the video above and then discuss the new season-six scenes in the comments section.


Now that George is gone, Grey's has found a few replacement actors...or animals.