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Eminem, 50 Cent, Dr. Dre

KMazur/Getty Images for Sirius Satellite Radio

He's baaaaaaaaaack.

Eminem, with assists from high-powered pals 50 Cent and Dr. Dre, has landed at No. 1 on the charts—and in the record books—with his latest single, "Crack the Bottle."

The track was (legally) downloaded a record 418,000 times in its first week and easily bounced Kelly Clarkson's "My Life Would Suck Without You" from the top slot on Billboard's Hot 100.

It marks his second No. 1, after 2002's "Lose Yourself." For Dr. Dre and 50 Cent, it's trips three and four.

"Crack the Bottle" is the lead single from Em's forthcoming Relapse album, but it's also likely to appear on Fiddy's own Before I Self Destruct, out next month. Dr. Dre's Detox, also expected shortly. ("Crack the Bottle," Relapse, Detox, Before I Self Destruct…we sense a pattern here.)

The "three-headed monster," as Fiddy calls them, previously collaborated on 2004's "Encore," the title track from Em's last studio album.