On Friday, the talk show host criticized Rob Kardashian for "giving up," and dating the model, who in her words, "comes from the world of the [stripper] pole." She continued to accuse Chyna of "taking full advantage" of Rob and his family's status for financial gain.
Chyna responded the following day, defending her love for Rob and spewing some serious venom at Williams.
"Wendy Bitch you're cruisin'," she wrote on Instagram. "Honestly, truly.. You go out there talking about my family like you just hit the pipe backstage!"
She continued, "When I decided to do this show I knew I would be letting the world see us. But your horse face ass woke up on the wrong side of the stable and decide to go overboard with your f--k boy comments. Bitch f--k you ! "P" body ass hoe," the message concluded.
The Rob & Chyna star certainly isn't alone in her harsh feelings. Check out Williams' biggest feuds below:
Beyoncé The talk show host unleashed some serious issues with the BeyHive when she went after Queen B...twice!
In 2012, she discussed Bey's documentary, criticizing the singer's communication skills.
"I am a Beyoncé fan. I'm going to be watching this documentary even if she doesn't introduce us to new stuff. I'm watching," Williams told her audience at the time. "I'm watching because fortunately one of the TVs in our kitchen has closed captioning, so I'll be able to understand what she says. You know Beyoncé can't talk. Beyoncé sounds like she has a fifth-grade education. She can't talk."
Earlier this year, she also criticized Bey's Lemonade album, accusing her of manipulating the media to sell albums. She even went as far as stating she believes Bey and Jay Z paid Rachel Roy to take part in their drama.
Steve Granitz/WireImage; Dimitrios Kambouris/Getty Images
"She's 21. She'll forever look 12," Williams said as the audience laughed. "And I don't mean that in a good way. It's nice to look younger than you are, but when you look too young and then you're short—she's only like 4'11". I don't look at her as, like, a woman."
The comments sparked controversy over the fact the Williams seemed to be body shaming Grande. It even prompted the hashtag #CancelWendyWilliams to trend on Twitter as fans of Grande banned together to try and get the show taken off air.
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Lil' Kim She may be under five feet tall, but no one really wants to mess with Lil' Kim...unless you're Wendy Williams.
The talk show host poked fun at the rapper's, er, altered face in 2013, saying, "Do you want to talk about Lil' Kim and that face of hers? It's filled so tight now, Kim, it looks like a pin would just pop you."
Kim responded angrily on Twitter calling her a "hating bitch" and even suggested she hooked up with Biggie. "@WendyWilliams Stop hating on me because U sucked Big's d--k & he didn't want nothing to do with yo ass after that," she wrote, adding, "@WendyWilliams it's time for the world to know the real. I'm not playing with yo ass no more. Let's get it!!!!!"
NeNe Leakes The Real Housewives of Atlanta star and the talk show host have gone back and forth for quite some time.
In 2014, Williams criticized the reality star for "defacing" an expensive Hermes Birkin bag. NeNe held no punches when it came to her response, writing an open letter in which she said: "What you need to do is stop spewing hate! When it comes to gossip you are the lowest of the low!"
By the way, Leakes also noted the bag was part of a charity fundraiser.
Their drama has also stemmed from comments made about one another's relationship. Leakes did not take too kindly when Williams said she felt her relationship "lacked chemistry" with her husband Gregg Leakes. "She don't know s--t about my relationship," the reality star responded. "Have you ever seen her and Kevin [Hunter] kiss? Yuck."
Holly Robinson: Williams made it clear that she wasn't a big fan of Holly and Rodney Peete's reality show, For Peete's Sake.
"Holly, Rodney, You know I love you Peetes. I tried but I got to tell you something. There's no place on TV anywhere it seems for shows like this," Williams said. "Holly's got the cute kids with Rodney. They've been married forever, but I don't think people care."
Robinson responded on Twitter, writing, "Dear @WendyWilliams #ForPeetesSake is resonating deeply esp w special needs #autism families. I know positivity isn't ur thing but it's OK," she tweeted. "If u think #ForPeetesSake's only abt cute kids n 80 yr mom dating then u didn't watch it. spraying #shade repellent on U."
The Real Housewives of Atlanta star clapped back on Twitter, sharing a screengrab of an emailed from Williams' show to ask her to appear the following week and writing, "Absolutely appalling!! @wendywilliams how disgusting for you to insinuate I 'faked' my mini stroke on your show this morning!! You mad cause I didn't come on your show! This clearly shows your warped mentality!!"
Rimes fired back on Twitter, writing, "All I know is Wendy Williams done pissed my mamma off! I don't wanna be in her path. To say, 'I've reserved myself a place in hell?!' I'm incredibly disappointed to see someone with that kind of platform use it for such negativity and could be so mean and judgmental about a situation they know nothing about."
She added, "I don't like how it happened either, said it a million times, but this is out of control."
However, the drama seems to be water under the bridge now, considering LeAnn and her hubby joined Williams show the following year.