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Charlize Theron wasn't wearing one of her usual body hugging dresses at last night's amfAR Inspiration Gala in Los Angeles.

Instead, the Oscar-winner opted for a loose fitting lacey gown with a black jacket.

"Yes, I am very fat right now," Theron said after Chelsea Handler cracked a joke about her weight gain.

Theron actually packed on about 30 pounds for her role in the upcoming comedy Tully as a mom whose brother hires her a nanny just after she gives birth to her third child.

But Theron certainly wasn't at the HIV/AIDS fundraiser to talk about her waistline. She received this year's Inspiration Award for her work in fighting the disease with the Charlize Theron Africa Outreach Project.

"When I went home to speak at the opening of the International AIDS conference [in July], I stood in front of an audience of thousands and made a plea to end the deadly stigma and discrimination that puts the burden of AIDS on the world's most vulnerable people," Theron said. "I argued that we should focus on the ones that are hardest to reach, the poor, young people, women, girls, gay and transgender people—the people bearing the brunt of the epidemic.

"It wasn't long after I gave this speech talking about how we couldn't forget the most vulnerable among us that I realized I had forgotten someone," she continued. "I had forgotten to mention sex workers, some of the most stigmatized people in the world and felt terrible."

But, she said, there was a lesson to be learned by her oversight. "Despite our best intentions, sometimes people are still falling through the cracks and too many are not being seen," Theron said. "It's tough to admit that as much progress as we've made, sometimes it feels like we're failing the ones that need us the most."

While Theron believes a cure for HIV/AIDS is as close as just around the corner, she emphasized that there's still work to be done. "We need big and bold investments in outreach," she said. "We need big bold ideas to fight poverty [and] end discrimination in hard to reach places.

"We need big bold messages to fight apathy in our governments and in our own communities. And if we're going to end stigma, we're going to have to check our own biases and ask who are we missing when we talk about end AIDS?"

The gala's presenters and guests included Heidi Klum, Jesse Metcalfe, Jon Hamm, Courtney Love, Lea Michele, Fashion Police's Brad Goreski and Kelsey Grammer. Cadillac, Harry Winston and MAC Cosmetics sponsored the event, which also featured a performance by Jason Derulo.