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Karate Kid, Toy Story 3, Grown-ups, Knight and Day

Sony Pictures; Disney/Pixar; Columbia TriStar; Frank Masi/Twentieth Century Fox and Regency Enterprises

Last weekend Toy Story 3 had the second biggest opening of 2010, bringing in $109 million. Of course, it didn't have a whole lot of competition (Jonah Hex and its paltry $5 mil, anyone?)

This weekend's a bit of a different story:

First of all, Tom Cruise and Cameron Diaz have paired up for the action comedy Knight and Day, and while it probably won't be as big as Toy Story 3, it has the potential to grab the top spot at the box office.

But wait, there's more on the comedy front. Grown Ups with Adam Sandler, Kevin James, Chris Rock, David Spade and Rob Schneider is also hitting theaters this weekend, and if you're looking for adults-being-out-of-place-at-a-water-park humor, then this just might be your thing.

Or maybe you're still playing catch-up and will head out to see Jaden Smith and Jackie Chan perfect their swan kicks in The Karate Kid?

Vote now and check in with E! movie guy Ben Lyons on Daily 10, weeknights at 7:30 p.m., for all your movie scoop!