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Katherine Heigl, Grey's Anatomy, There's No "I" in Team

ABC/ERIC MCCANDLESS

While her fate up in the air on Grey's Anatomy, Katherine Heigl's will keep plenty busy even if her tenure at Seattle Grace comes to a tragic end.

She will join Ashton Kutcher in the Lionsgate thriller Five Killers, which, depending on how her Seattle Grace storyline plays out, will either be her Grey's hiatus movie or her first post-op project.

Killers will see Heigl playing a woman who marries her very own McDreamy while on vacation only to find her newlywed life threatened after learning the couple next door are assassins out to kill her and her hubby. The film will reunite Heigl with Robert Luketic, who directed her in the upcoming rom-com The Ugly Truth.

Cameras roll next month in Atlanta and the south of France.

Meanwhile, Sandra Bullock's got game and Owen Wilson's ready to meet some Little Fockers...

Bullock has signed to star in Warner Bros.' football-themed dramedy The Blindside. Per Variety, Bullock will play the matriarch of a conservative, well-heeled suburban household that takes in a homeless teen who's a top pick for the NFL draft.

According to the Hollywood Reporter, Owen Wilson may have an expanded role in Little Fockers, the latest sequel in the blockbuster Meet the Parents franchise. He's in talks to reunite with stars Ben Stiller, Teri Polo and Robert De Niro and reprise the role of Kevin Rawley, the Jesus-loving ex-boyfriend of Polo's character. Jay Roach, who helmed the first two installments, will produce this time around. New directors being considered include Paul Weitz (About a Boy), David Wain (Role Models), and Peyton Reed (Yes Man).

Liev Schreiber is in final talks to aboard Columbia Pictures' Salt, a spy thriller starring Angelina Jolie as a CIA officer who's suspected of being a mole for the Russians. Schreiber would play her boss. Phillip Noyce (Patriot Games)  starts shooting this month in New York.

Comedy Central has given the go-ahead for a half-hour comedy starring Michael Ian Black and Michael Showalter. Michael and Michael Have Issues is a 30 Rock-type show about the backstage goings on at a sketch program and is expected to debut in July.

Nelly has signed on for the cleverly titled Nelly's Night in Vegas, which will see the "Hot in Herre" hip-hopster performing and interacting with various celebrities in a talk show format replete with sidekick, house band, and even a game show element.